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:: Volume 24, Issue 3 (7-2012) ::
J Islam Dent Assoc Iran 2012, 24(3): 111-121 Back to browse issues page
Approach to Orofacial Granulomatosis and Review of Literature
Abbas Javadzade1, Ates sa Pakfetrat1, Farnaz Falaki2, Amir Seyyedi 3
1- Associate Professor, Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences. Mashhad, Iran
2- Assistant Professor, Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences. Mashhad, Iran
3- Assistant Professor, Department of Oral Medicine, School of Dentistry, Urmia University of Medical Sciences. Urmia, Iran , seyyedia871@mums.ac.ir
Abstract:   (6425 Views)

 

  Background and Aim : Orofacial granulomatosis (OFG) comprises a group of diseases characterized by non-caseating granulomatous inflammation affecting the soft tissues of the oral and maxillofacial region.

  Wiesenfeld introduced the term orofacial granulomatosis in 1985 for the first time. The precise cause of OFG is unknown however, some theories have been suggested including allergy, infection and genetic predisposition.

  The clinical presentation can be highly variable, making the diagnosis difficult to establish.

  The aim of this review was to define clinical features, differential diagnosis and treatment protocols of OFG .

  Materials and Methods : All English articles from 1950 to 2010 in Pubmed, InterScience, ScienceDirect, Google Scholar databases were searched using the keywords : orofacial granulomatosis, approach, and treatment. Persian articles were also selected from Iran Medex .

  Results and Conclusion : Because of the relatively nonspecific clinical findings associated with a variety of granulomatous diseases, the diagnosis of orofacial granulomatous often presents a dilemma for the clinician. The most common differential diagnosis includes Crohn's disease, sarcoidosis, and infection. However, a variety of other conditions may be associated with granuloma formation. Often an extensive clinical, microscopic, and laboratory evaluation may be required to reach to definite diagnosis and proper treatment .

Keywords: Orofacial granulomatosis, Approach, Treatment
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Type of Study: Orginal | Subject: Oral Medicine
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Javadzade A, Pakfetrat A S, Falaki F, Seyyedi A. Approach to Orofacial Granulomatosis and Review of Literature. J Islam Dent Assoc Iran. 2012; 24 (3) :111-121
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Volume 24, Issue 3 (7-2012) Back to browse issues page
Journal of Islamic Dental Association of Iran

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