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:: Volume 24, Issue 3 (7-2012) ::
2012, 24(3): 122-138 Back to browse issues page
Effects of Different Growth Factors on New Bone Formation: A Systematic Review
Hosain Behnia , Arash Khojasteh , Mohammad Esmaeelinejad , Navid Naghdi
, arashkhojasteh@gmail.com
Abstract:   (8234 Views)

Effects of Different Growth Factors on New Bone Formation: A Systematic Review

  H . Behnia 1 , N. Naghdi 2 , M . Esmaeelinejad 3 , A . Khojasteh 4

  1 Professor and Chairman , Department of Oral and Maxillofacial Surgery , School of Dentistry , Shahid Beheshti University of Medical Sciences . Tehran, Iran . 2 Resident of Oral and Maxillofacial Surgery , Isfehan University of Medical Sciences . Isfehan, Iran .

  3 Resident of Oral and Maxillofacial Surgery Shahid Beheshti University of Medical Sciences . Tehran, Iran .

  4 Assistant Professor, Department of Oral and Maxillofacial Surgery , School of Dentistry , Shahid Beheshti University of Medical Sciences And Head of the Division of Basic Sciences, Dental Research Center . Tehran, Iran .

  (Received 2 March, 2011 Accepted 1 Dec, 2011)

  Abstract

  Background and Aim: Using different osteogenic growth factors, which is still under investigation, is a favorable method for bone regeneration. This systematic review is aimed at evaluating the effects of different growth factors and their carriers on osteogenesis .

  Materials and Methods: Electronic databases (Medline, EMBase and Cochrane) were studied by the authors for articles published from 1999 to October 2010. Clinical and animal studies evaluating bone formation by applying a specific growth factor and the related carrier were included in this investigation. Obtained data were organized in a table and evaluated through a qualitative analysis .

  Results: Sixty-nine studies most of which evaluated the effects of BMP-2 osteogenesis in different models were included in this study. Totally, twenty-five carriers were applied with different growth factors in the experiments. Among these carriers, poly lactic– co glycolic acid (PLGA), hydroxy apatite/tricalcium phosphate/absorbable collagen sponge (HA/TCP/ACS) and BioOss were the most frequently used carriers with the growth factors in bone regeneration studies.

  Conclusion: The current evidence, although not strong enough, confirms that BMP-2 has more favorable results in osteogenesis compared with other factors. The carrier scaffold, methods of measurement (histologic or radiographic), type of animal, defect diameter and the length of follow-up are the variables that should be matched before reaching definite results for the effect of growth factors in bone regeneration .

  Key Words : Growth factors – Bone regeneration – New bone formation – Carrier – BMP

Corresponding Author: Dr. Khojasteh A . , Assistant Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences And Head of the Division of Basic Sciences, Dental Research Center. Tehran, Iran.

  e.mail: arashkhojasteh@gmail.com

Keywords: Growth factors, Bone regeneration, New bone formation, Carrier, BMP
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Type of Study: Research | Subject: Oral and Maxillofacial
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Behnia H, Khojasteh A, Esmaeelinejad M, Naghdi N. Effects of Different Growth Factors on New Bone Formation: A Systematic Review. Journal of Islamic Dental Association of IRAN (JIDA) . 2012; 24 (3) :122-138
URL: http://jidai.ir/article-1-1253-en.html


Volume 24, Issue 3 (7-2012) Back to browse issues page
Journal of Islamic Dental Association of Iran

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