Comparison of Salivary Cotinine Concentration in Cigarette  Smokers, Water Pipe Smokers and Non–Smokers

Rabiei , Maryam; Rahbar Taramsar , Morteza; Sadegh Kanjani , Mehrdad; Kazemnezhad Leyli , Ehsan; Masoudi Rad , Hosain; Jafari Farshami , Mohammad

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Journal of Islamic Dental Association of Iran

Volume 26, Issue 1 (1-2014)

J Islam Dent Assoc Iran 2014, 26(1): 39-45

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Comparison of Salivary Cotinine Concentration in Cigarette Smokers, Water Pipe Smokers and Non–Smokers

Maryam Rabiei ^*¹, Morteza Rahbar Taramsar², Mehrdad Sadegh Kanjani³, Ehsan Kazemnezhad Leyli⁴, Hosain Masoudi Rad⁵, Mohammad Jafari Farshami⁶

1- Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Guilan University of Medical Sciences. Guilan, Iran , rabiei@gums.ac.ir
2- Assistant Professor, Department of Legal Medicine and Toxicology, School of Medicine, Guilan University of Medical Sciences. Guilan, Iran
3- PHD Reference laboratory, Guilan University of Medical Sciences. Guilan, Iran
4- Assistant Professor, Department of Biostatistics, School of Medicine, Guilan University of Medical Sciences. Guilan, Iran
5- Assistant Professor, Department of Endodontics, School of Dentistry, Guilan University of Medical Sciences. Guilan, Iran
6- Dentist

Abstract: (6322 Views)

Background and Aim : Water pipe smoking has become a public health hazard. The aim of this study was to measure and compare the concentration of salivary cotinine in cigarette smokers, water pipe smokers and nonsmokers .

Materials and Methods : Forty-eight volunteers (16 cigarette smokers, 16 water pipe smokers and 16 nonsmokers) participated in this cross-sectional study. High sensitivity Salivary Cotinine Quantitative enzyme immunoassay kit was used to measure the salivary cotinine concentration. Non-parametric Kruskal Wallis test, Pearson’s correlation coefficient and linear regression were used to determine the correlation between number of cigarettes smoked and concentration of cotinine .

Results : The mean concentration of salivary cotinine was 223.74(±181.56) ng/ml (the highest) in cigarette smokers, 106.24 (±135.23) ng/ml in water pipe smokers and 0.73(±1.24) ng/ml in nonsmokers. The difference in this respect among the 3 groups was statistically significant (P<0.0001). In smokers, the level of salivary cotinine increased by 1.84 ng/ml per each time of cigarette smoking per week. This increase was 14.57 ng/ml per each time of water pipe consumption per week .

Conclusion : The mean concentration of salivary cotinine was significantly higher among cigarette smokers compared to water pipe smokers and nonsmokers. However, one time consumption of water pipe caused a greater rise in salivary cotinine level compared to cigarette smoking .

Keywords: Cotinine, Saliva, Smoking, Tobacco

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Type of Study: Orginal | Subject: Oral Medicine

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Rabiei M, Rahbar Taramsar M, Sadegh Kanjani M, Kazemnezhad Leyli E, Masoudi Rad H, Jafari Farshami M. Comparison of Salivary Cotinine Concentration in Cigarette Smokers, Water Pipe Smokers and Non–Smokers. J Islam Dent Assoc Iran. 2014; 26 (1) :39-45
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