[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 28, Issue 2 (4-2016) ::
J Islam Dent Assoc Iran 2016, 28(2): 78-85 Back to browse issues page
Assessment of the Relationship Between Stress and Oral Lichen Planus: A Review of Literature
Farzaneh Agha Hosseini * 1, Mahdieh Sadat Moosavi2, Maryam Sadat Sadrzadeh Afshar2, Nafiseh Sheykh Bahaei3
1- Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences,Department of Oral Medicine, Schoolof Dentistry, Tehran University of Medical Science, The academy of medical sciences, Tehran, Iran , Aghahose@sina.tums.ac.ir
2- Assistant Professor, Dental Research Center, Dentistry Research Institute, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Science, Tehran,Iran
3- Assistant Professor,Department of Oral Medicine, School of Dentistry, Kashan University of Medical Science, Kashan,Iran
Abstract:   (3196 Views)

Background and Aim: Oral lichen planus (OLP) is a chronic inflammatory lesion. Psychological stress occurs when someone senses that environmental demands exceed his/her adaptive capability. Stress, anxiety, and depression have frequently been mentioned as possible factors related to the development of OLP, although this association remains controversial. In most studies, a positive correlation was found between psychological stress and OLP, although some found no significant association. In this review, we assess the possible role of psychological stress in the etiopathogenesis of OLP.

Materials and Methods: The methodological approach of this study was to search major databases from 1985-2014, using "oral lichen planus"," stress", "anxiety", "depression" and "psychological disorder” as search terms.
Results: A total of 45 scientific papers and abstracts in English were reviewed, and 10 articles met the necessary requirements. Stress evaluation methods of these articles were questionnaire, genetic polymorphisms at DNA level, measurement of body substances like hormones, and effect of drug therapy of psychiatric disorders on OLP patients. In order to include a study, OLP in patients must have been proven by clinical and histopathological criteria. Exclusion criteria were not explicit stating the OLP diagnosis, an inadequate number of the test subject in experimental and control groups, discrepancy (inconsistency) in sex and age between the case and control groups, and unreliable method of stress measurements.
Conclusion: Higher levels of stress in patients with OLP were confirmed. Reducing psychological stress and well-being of patients is an important factor that should be considered in the treatment of OLP.

Keywords: Stress, Psychological, Lichen planus, Oral, Anxiety
Full-Text [PDF 346 kb]   (3081 Downloads)    
Type of Study: Review | Subject: Oral Medicine
1. Chaudhary S. Psychosocial stressors in oral lichen planus. Aust Dent J. 2004 Dec;49(4):192-5.
2. Agha-Hosseini F, Mirzaii-Dizgah I, Farmanbar N, Abdollahi M. Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcino-ma. J Oral Pathol Med. 2012 Nov;41(10):736-40.
3. Agha-Hosseini F, Mirzaii-Dizgah I, Abdollahi M, Akbari-Gillani N. Efficacy of IMOD in the treatment of orallichen planus. Open J Stomatol. 2011 June;1(2):13-7.
4. Delavarian Z, Javadzadeh-Bolouri A, Dalirsani Z, Arshadi HR, Toofani-Asl H. The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorder. Med Oral Patol Oral Cir Bucal. 2010 Mar 1;15(2):e322-7.
5. Pokupec JS, Gruden V, Gruden V Jr. Lichen ruber planus as a psychiatric problem. Psychiatr Danub. 2009 Dec;21(4):514-6.
6. Agha-Hosseinil F, Khalili M, Rohani B. Immunohistochemistry analysis of P53 and Ki-67 proteins in oral lichen planus and normal oral mucosa. Iran J Public Health. 2009Apr;38(2):37-43.
7. Ivanovski K, Nakova M, Warburton G, Pesevska S, Filipovska A, Nares S, et al. Psychological profile in oral lichen planus. J Clin Periodontol. 2005 Oct;32(10):1034-40.
8. Colella G, Gritti P, De Luca F, de Vito M. The psychopathological aspects of oral lichen planus (OLP). Minerva Stomatol. 1993 Jun; 42(6):265-70.
9. Aghahosseini F, Arbabi-Kalati F, Fashtami LA, Djavid GE, Fateh M, Beitollahi JM. Methylene blue-mediated photodynamic therapy: a possi-ble alternative treatment for oral lichen planus. Lasers Surg Med. 2006 Jan;38(1):33-8.
10. Vallejo MJ, Huerta G, Cerero R, Seoane JM. Anxiety and depression as risk factors for oral lichen planus. Dermatology. 2001;203(4):303-7.
11. Lundqvist EN, Wahlin YB, Bergdahl M, Bergdahl J. Psychological health in patients with genital and oral erosive lichen planus. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):661-6.
12. Soto Araya M, Rojas Alcayaga G, Esguep A. Association between psychological disorders and the presence of Oral lichen planus, Burning mouth syndrome and Recurrentaphthous stoma-titis. Med Oral. 2004 Jan-Feb;9(1):1-7.
13. Pourshahidi S, Ebrahimi H, Andisheh Tadbir A. Evaluation of the Relationship between Oral Lichen Planus and Stress. J Dent (SUMS). 2011 Apr; 12(1):43-7.
14. Shah B, Ashok L, Sujatha GP. Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. Indian J Dent Res. 2009 Jul-Sep;20(3):288-92.
15. Perdigão PF, Guimarães AL, Victoria JM, Xavier GM, Romano-Silva MA, Gomez RS. Serotonin transporter gene polymorphism (5-HTTLPR) in patients with oral lichen planus. Arch Oral Biol. 2007 Sep;52(9):889-93.
16. Girardi C, Luz C, Cherubini K, de Figueiredo MA, Nunes ML, Salum FG. Salivary cortisol and dehydroepiandrosterone (DHEA) levels, psychological factors in patients with oral lichen planus. Arch Oral Biol. 2011 Sep;56(9):864-8.
17. Cohen S, Janicki-Deverts D, Miller GE. Psychological Stress and Disease. JAMA. 2007 Oct 10;298(14):1685-7.
18. Steimer T. The biology of fear-and anxiety-related behaviors. Dialogues Clin Neurosci. 2002 Sep; 4(3):231-49.
19. Hagerty BM, Williams A. The effects of sense of belonging, social support, conflict, and loneliness on depression. Nurs Res. 1999 Jul-Aug 1;48(4):215-9.
20. Mohamadi Hasel K, Besharat MA, Abdolhoseini A, Alaei Nasab S, Niknam S. Relationships of Personality Factors to Per-ceived Stress, Depression, and Oral Lichen Planus Severity. Int J Behav Med. 2013 Jun;20(2):286-92.
21. Xie H, Li B, Li L, Zou XL, Zhu CR, Li Y, et al. Association of increased circulating catecholamine and glucocorticoid levels with risk of psychological problems in oral neoplasm patients. PLoS One. 2014 Jul 21;9(7):e99179.
22. Pippi R, Patini R, Ghiciuc CM, Sandu RB, Pasquali V, Scaccianoce S, et al. Diurnal trajectories of salivary cortisol, salivary α-amylase and psychological profiles in oral li-chen planus patients. J Biol Regul Homeost Agents. 2014 Jan-Mar;28(1):147-54.
23. Ranpise SG, John A. Urinary and Salivary Estimation of 17-Ketosteroid as an indicator in stress-induced lichen planus and Recurrent Aphthous stomatitis. J Indian Acad Oral Med & Radio. 2011July-Sept;23(3):295-9.
24. Stojanovich L, Marisavljevich D. Stress as a trigger of autoimmune disease. Autoimmun Rev. 2008 Jan;7(3):209-13.
25. Rhodus NL, Cheng B, Ondrey F. Th1/Th2 Cytokine Ratio in Tissue Transudates from Patients with Oral Lichen Planus. Mediators Inflamm. 2007;2007:19854.
26. Kalogerakou F, Albanidou-Farmaki E, Markopoulos AK, Antoniades DZ. Detection of T cells secreting type 1 and type 2 cytokines in the peripheral blood of patients with oral lichen planus Hippokratia. 2008;12(4):230-5.
27. Zhang J, Zhou G. Green tea consumption: an alternative approach to managing oral lichen planus. Inflamm Res. 2012 Jun;61(6):535-9.
28. Allen CM, Beck FM, Rossie KM, Kaul TJ. Rela-tion of stress and anxiety to oral lichen planus. Oral Surg Oral Med Oral Pathol. 1986 Jan; 61(1): 44-6.
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Agha Hosseini F, Sadat Moosavi M, Sadat Sadrzadeh Afshar M, Sheykh Bahaei N. Assessment of the Relationship Between Stress and Oral Lichen Planus: A Review of Literature . J Islam Dent Assoc Iran. 2016; 28 (2) :78-85
URL: http://jidai.ir/article-1-1860-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 28, Issue 2 (4-2016) Back to browse issues page
Journal of Islamic Dental Association of Iran


This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4341