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:: Volume 31, Issue 2 (4-2019) ::
J Islam Dent Assoc Iran 2019, 31(2): 87-92 Back to browse issues page
Immunohistochemical Evaluation of CD86 Expression in Ero-sive Oral Lichen Planus
Masoumeh Mehdipour1, Ali Taghavi Zenouz2, Noushin Jalayer Naderi3, Ayla Bahramian4, Narges Gholizadeh 5
1- Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
3- Associate Professor, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shahed University, Tehran, Iran
4- Assistant Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
5- Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran , n-gholizadeh@sina.tums.ac.ir
Abstract:   (371 Views)
Background and Aim: Lichen planus is an inflammatory autoimmune mucocutaneous disease. Stimulation of T cells and antigen-presenting cells (APCs), such as dendritic cells, mediates apoptosis of keratinocytes and basement membrane destruction. The aim of this study was to investigate the expression of one of the immune cell markers (CD86) in erosive oral lichen planus.
Materials and Methods: In this paired analytical cross-sectional study, 22 patients with erosive oral lichen planus were included. Biopsies from oral lesions of these pa-tients were obtained. The surrounding normal marginal mucosa around these lesions served as controls. To visualize CD86-expressing cells, immunohistochemistry (IHC) pro-cesses were used. Data were transferred to SPSS 11.0 software and were analyzed us-ing marginal homogeneity test.
Results: This study showed an increased number of CD86-expressing cells in erosive lichen planus lesions, while in normal mucosa, no cells were found to express CD86. Marginal homogeneity test revealed that the difference in positivity and negativity between the groups was significant (P<0.001).
Conclusion: A high expression of CD86 in erosive lichen planus lesions shows an increased activation of APCs, while these cells are inactive in normal mucosa.
Keywords: CD86, Dendritic Cells, Lichen Planus
Full-Text [PDF 605 kb]   (105 Downloads)    
Type of Study: Orginal | Subject: Oral Medicine
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Mehdipour M, Taghavi Zenouz A, Jalayer Naderi N, Bahramian A, Gholizadeh N. Immunohistochemical Evaluation of CD86 Expression in Ero-sive Oral Lichen Planus . J Islam Dent Assoc Iran. 2019; 31 (2) :87-92
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Volume 31, Issue 2 (4-2019) Back to browse issues page
Journal of Islamic Dental Association of Iran

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