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:: Volume 31, Issue 2 (4-2019) ::
J Islam Dent Assoc Iran 2019, 31(2): 98-108 Back to browse issues page
In Vitro Comparison of the Efficacy of Cumin Extract and Fluconazole Against Candida Strains
Masoumeh Mehdipour1, Narges Gholizadeh2, Maryam-Sadat Sadrzadeh-Afshar3, Nasim Hematpoor4, Parisa Kalaee4, Mojdeh Hakemi Vala5, Zahra Namazi 6
1- Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
3- Assistant Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Aja University of Medical Sciences, Tehran, Iran
4- Dentist, Private Practice, Tehran, Iran
5- Associate Professor, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- PhD Candidate, Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (176 Views)
Background and Aim: Fungal infections are the most common opportunistic infections; when accompanied by widespread infections, such as acquired immune de-ficiency syndrome (AIDS), they cause a worldwide health crisis. Therefore, treatment of these infections is seen as one of the health challenges. Medicinal herbs can be used as rich sources of treatment due to their fewer side effects. Currently, Cuminum cyminum (cumin) is considered to have antimicrobial properties. The aim of this study was to compare the efficacy of cumin extract and flu-conazole against Candida species in vitro.
Materials and Methods: In this in-vitro experimental study, aqueous and ethanolic extracts of cumin were prepared through maceration. The minimum inhibitory concentrations (MIC) of aqueous and alcoholic extracts of cumin against Candida albicans and Candida glabrata were determined using the microdilution method. Fluconazole was simultaneously used as an antifungal agent for comparison.
Results: Alcoholic and aqueous extracts of cumin were able to prevent the growth of Candida albicans at MICs of 100 mg/ml and 200 mg/ml, respectively. Both aqueous and alcoholic extracts of cumin were able to prevent the growth of Candida glabrata at 200 mg/ml concentration. Fluconazole was able to inhibit the growth of Candida albicans and Candida glabrata at MICs of 0.12 mg/ml and 0.03 mg/ml, respectively.
Conclusion: According to the findings of this study, both aqueous and alcoholic extracts of cumin exhibited measurable inhibitory activities against Candida species.
Keywords: Cuminum cyminum, Candida albicans, Candida glabrata, Fluconazole
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Type of Study: Orginal | Subject: Oral Medicine
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Mehdipour M, Gholizadeh N, Sadrzadeh-Afshar M, Hematpoor N, Kalaee P, Hakemi Vala M et al . In Vitro Comparison of the Efficacy of Cumin Extract and Fluconazole Against Candida Strains . J Islam Dent Assoc Iran. 2019; 31 (2) :98-108
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Volume 31, Issue 2 (4-2019) Back to browse issues page
Journal of Islamic Dental Association of Iran

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