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:: Volume 32, Issue 1 And 2 (In Progress 2020) ::
J Islam Dent Assoc Iran 2020, 32(1 And 2): 30-36 Back to browse issues page
Comparison of Salivary Peroxidase in HIV Positive Patients and Healthy Controls: A Case-Control Study
Fatemeh Ahmadi-Motamayel1, Samaneh Vaziri–Amjad * 2, Poorandokht Davoodi3, Mohammad Taghi Goodarzi4, Jalal Poorolajal5, Hamidreza Abdolsamadi6
1- Associate professor, Dental Implant Research Center and Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Assistant professor, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , samanehdent83@yahoo.com
3- Assistant Professor, Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran
4- Professor, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Associate Professor, Research Center for Health Sciences and Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
6- Full Professor, Dental Implant Research Center and Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (45 Views)
Background and Aim: Saliva, as an easy diagnostic tool, has various defense mecha-nisms such as immunological, enzymatic and antioxidant defense systems. Salivary peroxidase is one of the most important salivary antioxidants. Human immunodeficiency virus (HIV) positive and acquired immunodeficiency syndrome (AIDS) patients have decreased antioxidant and increased oxidative stress levels. Therefore, the aim of this study was to compare the level of salivary peroxidase in HIV positive patients and healthy controls.
Materials and Methods: In this case-control study, 49 HIV positive patients and 49 healthy controls were selected as the case and control group, respectively. Demographic, clinical, and paraclinical information was recorded in a checklist. Next, 5 mL of unstimulated whole saliva was collected during 5 min in sterile Falcon tubes. Peroxidase activity of the saliva was measured by the Gelycol method. Data were ana-lyzed by SPSS 11 via t-test and Chi-square test.
Results: The salivary peroxidase level was slightly higher in the case group in comparison with the healthy control group, but this difference was not statistically significant (P=0.157). Dental status of the case group was significantly different from the control group (P=0.029). The mean age of the case group was also significantly higher than the control group (P=0.005). In the case group, females had a higher frequency than males.
Conclusion: The results showed slightly, but not significantly, higher level of peroxidase in the study group than the healthy controls. Minimal change in salivary peroxidase in HIV positive patients may be related to the early stage of their disease and good function of the immune system.
Keywords: Saliva, Peroxidases, HIV, Antioxidants
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Type of Study: Orginal | Subject: Oral Medicine
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Ahmadi-Motamayel F, Vaziri–Amjad S, Davoodi P, Goodarzi M T, Poorolajal J, Abdolsamadi H. Comparison of Salivary Peroxidase in HIV Positive Patients and Healthy Controls: A Case-Control Study. J Islam Dent Assoc Iran. 2020; 32 (1 and 2) :30-36
URL: http://jidai.ir/article-1-2101-en.html


Volume 32, Issue 1 And 2 (In Progress 2020) Back to browse issues page
Journal of Islamic Dental Association of Iran

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