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:: Volume 32, Issue 3 And 4 (10-2020) ::
J Islam Dent Assoc Iran 2020, 32(3 And 4): 75-82 Back to browse issues page
Effects of Non-Surgical Periodontal Therapy on Gingival Crevicular Fluid Levels of Interleukin-17 and Interleukin-23 in Patients with Periodontitis: A Clinical Trial
Maryam Haghi1, Mandana Sattari2, Fereshteh Shanei3, Ferial Taleghani *4
1- Periodontist, Private Practice, Tehran, Iran
2- Professor, Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Assistant Professor, Department of Periodontics, Faculty of Dentistry, Alborz University of Medical Sciences, Alborz, Iran
4- Associate Professor, Department of Periodontics, Faculty of Dentistry, Shahed University, Tehran, Iran , fr.perio@gmail.com
Abstract:   (187 Views)
Background and Aim: Considering the critical role of inflammatory responses in periodontal disease, knowledge about the immune system and cytokines seems nec-essary. The aim of this study was to evaluate the level of IL-23 and IL-17 in gingival crevicular fluid (GCF) of patients with chronic and aggressive periodontitis, before and after non-surgical periodontal therapy.
Materials and Methods: In the present clinical trial, GCF samples were collected from 54 patients (with aggressive and chronic periodontitis) before and after the ini-tial phase of periodontal therapy. The cytokine concentration was measured using ELISA. The Wilcoxon signed-rank test was performed to analyze the effect of non-surgical periodontal therapy on each group. The correlation between variables was investigated by the Spearman’s correlation coefficient.
Results: Non-surgical periodontal therapy in both groups significantly decreased the IL-17 and IL-23 levels (P<0.05). A significant correlation was noted between the con-centration of IL-23 and IL-17 before the treatment in the chronic periodontal group (P<0.05), while such a correlation was not seen in the aggressive periodontitis group (P>0.05).
Conclusion: Due to the reduction of IL-17 and IL-23 after nonsurgical periodontal therapy, these factors may play a role as mediators of periodontitis pathogenesis. Di-rect statistical correlation between the concentration of IL-17 and IL-23 before treat-ment in the chronic group shows the possible role of IL-23 in inducing Th-17 cells and production of IL-17.
Keywords: Aggressive Periodontitis, Chronic Periodontitis, Cytokines, Periodontal Debridement
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Type of Study: Orginal | Subject: Periodontology
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Haghi M, Sattari M, Shanei F, Taleghani F. Effects of Non-Surgical Periodontal Therapy on Gingival Crevicular Fluid Levels of Interleukin-17 and Interleukin-23 in Patients with Periodontitis: A Clinical Trial. J Islam Dent Assoc Iran. 2020; 32 (3 and 4) :75-82
URL: http://jidai.ir/article-1-2119-en.html


Volume 32, Issue 3 And 4 (10-2020) Back to browse issues page
Journal of Islamic Dental Association of Iran

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