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:: Volume 26, Issue 4 (10-2014) ::
J Islam Dent Assoc Iran 2014, 26(4): 226-232 Back to browse issues page
Adjunctive Low-Dose Aspirin plus Omega-3 Fatty Acid versus Low-Dose Doxycycline on Chronic Periodontitis
Shirin Zahra Farhad1, Shahram Amini1, Atefeh Mahdian2, Mehrdad Barkatain3, Morvarid Mafi *4
1- Assistant Professor, Department of Periodontics, School of Dentistry, Khorasgan Islamic Azad University. Isfahan, Iran
2- Dentist, Private Office, Isfahan, Iran
3- Assistant Professor, Department of Restorative Dentistry, School of Dentistry, Khorasgan Islamic Azad University. Isfahan, Iran
4- Assistant Professor, Department of Periodontics, School of Dentistry, Ahwaz University of Medical Sciences. Ahwaz, Iran , Morvarid.Ltk@gmail.com
Abstract:   (3768 Views)

Background and Aim: Host modulation therapy (HMT) has been considered as a new modality for treatment of periodontal disease. Omega-3 fatty acid has shown inhibitory and anti-inflammatory properties in treatment of inflammatory conditions such as perio-dontitis. This study compared the efficacy of omega-3 fatty acid and low-dose aspirin with doxycycline in treatment of chronic periodontitis.

Materials and Methods: Forty-five patients with chronic periodontitis were selected and their clinical periodontal parameters were measured. They received phase I of periodontal therapy and were randomly divided into three groups. Each group randomly received one of the following daily drug regimens: omega-3 fatty acid plus aspirin (80mg), doxycy-cline (20mg) and the placebo (control). Clinical parameters were measured again after six weeks. Wilcoxon test, paired t-test, Kruskal–Wallis test and one-way ANOVA were used to analyze the data.

Results: The mean values of bleeding on probing (BOP), periodontal pocket depth (PPD) and clinical attachment loss (CAL) in both test groups decreased significantly compared to the placebo group (p<0.05). The reductions in the omega-3 group were significantly greater than those in the doxycycline group (p<0.05).

Conclusion: Omega-3 fatty acid can improve clinical parameters of periodontal disease, even better than doxycycline, which is routinely used for HMT.

Keywords: Chronic periodontitis, Omega-3 fatty acid, Doxycycline
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Type of Study: Orginal | Subject: Periodontology
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Farhad S Z, Amini S, Mahdian A, Barkatain M, Mafi M. Adjunctive Low-Dose Aspirin plus Omega-3 Fatty Acid versus Low-Dose Doxycycline on Chronic Periodontitis. J Islam Dent Assoc Iran. 2014; 26 (4) :226-232
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Volume 26, Issue 4 (10-2014) Back to browse issues page
Journal of Islamic Dental Association of Iran

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